Ontology highlight
ABSTRACT:
SUBMITTER: Stomrud E
PROVIDER: S-EPMC4879483 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Stomrud Erik E Minthon Lennart L Zetterberg Henrik H Blennow Kaj K Hansson Oskar O
Alzheimer's & dementia (Amsterdam, Netherlands) 20151009 4
<h4>Introduction</h4>Ascertainment of the pattern and temporal change of biomarkers in preclinical (asymptomatic) sporadic Alzheimer's disease (AD) will increase knowledge about early pathogenesis and facilitate interventional therapeutic trials.<h4>Methods</h4>In this prospective longitudinal study, repeated cerebrospinal fluid (CSF) collections and cognitive evaluations were performed in cognitively healthy elderly individuals during a 9-year period.<h4>Results</h4>Low CSF β-amyloid (Aβ)42 lev ...[more]