Ontology highlight
ABSTRACT:
SUBMITTER: Hauffe R
PROVIDER: S-EPMC7308064 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Hauffe Robert R Stein Vanessa V Chudoba Chantal C Flore Tanina T Rath Michaela M Ritter Katrin K Schell Mareike M Wardelmann Kristina K Deubel Stefanie S Kopp Johannes Florian JF Schwarz Maria M Kappert Kai K Blüher Matthias M Schwerdtle Tanja T Kipp Anna P AP Kleinridders André A
JCI insight 20200604 11
Insulin receptor signaling is crucial for white adipose tissue (WAT) function. Consequently, lack of insulin receptor (IR) in WAT results in a diabetes-like phenotype. Yet, causes for IR downregulation in WAT of patients with diabetes are not well understood. By using multiple mouse models of obesity and insulin resistance, we identify a common downregulation of IR with a reduction of mRNA expression of selenoproteins Txnrd3, Sephs2, and Gpx3 in gonadal adipose tissue. Consistently, GPX3 is also ...[more]