Ontology highlight
ABSTRACT:
SUBMITTER: Shetty S
PROVIDER: S-EPMC5068261 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Shetty Sunil S Varshney Umesh U
Proceedings of the National Academy of Sciences of the United States of America 20161003 41
Ribosome biogenesis, a complex multistep process, results in correct folding of rRNAs, incorporation of >50 ribosomal proteins, and their maturation. Deficiencies in ribosome biogenesis may result in varied faults in translation of mRNAs causing cellular toxicities and ribosomopathies in higher organisms. How cells ensure quality control in ribosome biogenesis for the fidelity of its complex function remains unclear. Using Escherichia coli, we show that initiator tRNA (i-tRNA), specifically the ...[more]