Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC5069155 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Genetic epidemiology 20160822 7
Recent advancements in next-generation DNA sequencing technologies have made it plausible to study the association of rare variants with complex diseases. Due to the low frequency, rare variants need to be aggregated in association tests to achieve adequate power with reasonable sample sizes. Hierarchical modeling/kernel machine methods have gained popularity among many available methods for testing a set of rare variants collectively. Here, we propose a new score statistic based on a hierarchic ...[more]