Ontology highlight
ABSTRACT:
SUBMITTER: Lin JR
PROVIDER: S-EPMC5760082 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
PLoS genetics 20171227 12
Rare variants of major effect play an important role in human complex diseases and can be discovered by sequencing-based genome-wide association studies. Here, we introduce an integrated approach that combines the rare variant association test with gene network and phenotype information to identify risk genes implicated by rare variants for human complex diseases. Our data integration method follows a 'discovery-driven' strategy without relying on prior knowledge about the disease and thus maint ...[more]