Ontology highlight
ABSTRACT:
SUBMITTER: El Costa H
PROVIDER: S-EPMC5069472 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
El Costa Hicham H Gouilly Jordi J Mansuy Jean-Michel JM Chen Qian Q Levy Claude C Cartron Géraldine G Veas Francisco F Al-Daccak Reem R Izopet Jacques J Jabrane-Ferrat Nabila N
Scientific reports 20161019
The outbreak of the Zika Virus (ZIKV) and its association with fetal abnormalities have raised worldwide concern. However, the cellular tropism and the mechanisms of ZIKV transmission to the fetus during early pregnancy are still largely unknown. Therefore, we ex vivo modeled the ZIKV transmission at the maternal-fetal interface using organ culture from first trimester pregnancy samples. Here, we provide evidence that ZIKV strain circulating in Brazil infects and damages tissue architecture of t ...[more]