Ontology highlight
ABSTRACT:
SUBMITTER: Chinen T
PROVIDER: S-EPMC5071159 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Chinen Takatoshi T Kannan Arun K AK Levine Andrew G AG Fan Xiying X Klein Ulf U Zheng Ye Y Gasteiger Georg G Feng Yongqiang Y Fontenot Jason D JD Rudensky Alexander Y AY
Nature immunology 20160905 11
Regulatory T cells (T<sub>reg</sub> cells), which have abundant expression of the interleukin 2 receptor (IL-2R), are reliant on IL-2 produced by activated T cells. This feature indicates a key role for a simple network based on the consumption of IL-2 by T<sub>reg</sub> cells in their suppressor function. However, congenital deficiency in IL-2R results in reduced expression of the T<sub>reg</sub> cell lineage-specification factor Foxp3, which has confounded experimental efforts to understand th ...[more]