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An essential role for the IL-2 receptor in Treg cell function.


ABSTRACT: Regulatory T cells (Treg cells), which have abundant expression of the interleukin 2 receptor (IL-2R), are reliant on IL-2 produced by activated T cells. This feature indicates a key role for a simple network based on the consumption of IL-2 by Treg cells in their suppressor function. However, congenital deficiency in IL-2R results in reduced expression of the Treg cell lineage-specification factor Foxp3, which has confounded experimental efforts to understand the role of IL-2R expression and signaling in the suppressor function of Treg cells. Using genetic gain- and loss-of-function approaches, we found that capture of IL-2 was dispensable for the control of CD4+ T cells but was important for limiting the activation of CD8+ T cells, and that IL-2R-dependent activation of the transcription factor STAT5 had an essential role in the suppressor function of Treg cells separable from signaling via the T cell antigen receptor.

SUBMITTER: Chinen T 

PROVIDER: S-EPMC5071159 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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An essential role for the IL-2 receptor in T<sub>reg</sub> cell function.

Chinen Takatoshi T   Kannan Arun K AK   Levine Andrew G AG   Fan Xiying X   Klein Ulf U   Zheng Ye Y   Gasteiger Georg G   Feng Yongqiang Y   Fontenot Jason D JD   Rudensky Alexander Y AY  

Nature immunology 20160905 11


Regulatory T cells (T<sub>reg</sub> cells), which have abundant expression of the interleukin 2 receptor (IL-2R), are reliant on IL-2 produced by activated T cells. This feature indicates a key role for a simple network based on the consumption of IL-2 by T<sub>reg</sub> cells in their suppressor function. However, congenital deficiency in IL-2R results in reduced expression of the T<sub>reg</sub> cell lineage-specification factor Foxp3, which has confounded experimental efforts to understand th  ...[more]

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