Ontology highlight
ABSTRACT:
SUBMITTER: Hayashi S
PROVIDER: S-EPMC5074804 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Hayashi Shinichiro S Manabe Ichiro I Suzuki Yumi Y Relaix Frédéric F Oishi Yumiko Y
eLife 20161015
Krüppel-like factor 5 (Klf5) is a zinc-finger transcription factor that controls various biological processes, including cell proliferation and differentiation. We show that Klf5 is also an essential mediator of skeletal muscle regeneration and myogenic differentiation. During muscle regeneration after injury (cardiotoxin injection), Klf5 was induced in the nuclei of differentiating myoblasts and newly formed myofibers expressing myogenin <i>in vivo</i>. Satellite cell-specific <i>Klf5</i> delet ...[more]