Ontology highlight
ABSTRACT:
SUBMITTER: Song GJ
PROVIDER: S-EPMC5081471 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Experimental neurobiology 20161020 5
Protein tyrosine phosphatases (PTPs) are key regulatory factors in inflammatory signaling pathways. Although PTPs have been extensively studied, little is known about their role in neuroinflammation. In the present study, we examined the expression of 6 different PTPs (PTP1B, TC-PTP, SHP2, MEG2, LYP, and RPTPβ) and their role in glial activation and neuroinflammation. All PTPs were expressed in brain and glia. The expression of PTP1B, SHP2, and LYP was enhanced in the inflamed brain. The express ...[more]