Ontology highlight
ABSTRACT:
SUBMITTER: Diokmetzidou A
PROVIDER: S-EPMC5087667 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Diokmetzidou Antigoni A Soumaka Elisavet E Kloukina Ismini I Tsikitis Mary M Makridakis Manousos M Varela Aimilia A Davos Constantinos H CH Georgopoulos Spiros S Anesti Vasiliki V Vlahou Antonia A Capetanaki Yassemi Y
Journal of cell science 20160826 20
The association of desmin with the α-crystallin Β-chain (αΒ-crystallin; encoded by CRYAB), and the fact that mutations in either one of them leads to heart failure in humans and mice, suggests a potential compensatory interplay between the two in cardioprotection. To address this hypothesis, we investigated the consequences of αΒ-crystallin overexpression in the desmin-deficient (Des<sup>-/-</sup>) mouse model, which possesses a combination of the pathologies found in most cardiomyopathies, with ...[more]