Ontology highlight
ABSTRACT:
SUBMITTER: Patel JT
PROVIDER: S-EPMC5090061 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Patel Jennifer T JT Belsham Hannah R HR Rathbone Alexandra J AJ Wickstead Bill B Gell Christopher C Friel Claire T CT
Open biology 20161001 10
Kinesins that influence the dynamics of microtubule growth and shrinkage require the ability to distinguish between the microtubule end and the microtubule lattice. The microtubule depolymerizing kinesin MCAK has been shown to specifically recognize the microtubule end. This ability is key to the action of MCAK in regulating microtubule dynamics. We show that the α4-helix of the motor domain is crucial to microtubule end recognition. Mutation of the residues K524, E525 and R528, which are locate ...[more]