Ontology highlight
ABSTRACT:
SUBMITTER: Sundaram GS
PROVIDER: S-EPMC5090206 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Sundaram G S M GS Dhavale Dhruva D DD Prior Julie L JL Yan Ping P Cirrito John J Rath Nigam P NP Laforest Richard R Cairns Nigel J NJ Lee Jin-Moo JM Kotzbauer Paul T PT Sharma Vijay V
Scientific reports 20161102
Fluselenamyl (5), a novel planar benzoselenazole shows traits desirable of enabling noninvasive imaging of Aβ pathophysiology in vivo; labeling of both diffuse (an earlier manifestation of neuritic plaques) and fibrillar plaques in Alzheimer's disease (AD) brain sections, and remarkable specificity for mapping Aβ compared with biomarker proteins of other neurodegenerative diseases. Employing AD homogenates, [<sup>18</sup>F]-9, a PET tracer demonstrates superior (2-10 fold higher) binding affinit ...[more]