Ontology highlight
ABSTRACT:
SUBMITTER: Frost GR
PROVIDER: S-EPMC7316864 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Frost Georgia R GR Longo Valerie V Li Thomas T Jonas Lauren A LA Judenhofer Martin M Cherry Simon S Koutcher Jason J Lekaye Carl C Zanzonico Pat P Li Yue-Ming YM
Scientific reports 20200625 1
The emergence of PET probes for amyloid plaques and neurofibrillary tangles, hallmarks of Alzheimer disease (AD), enables monitoring of pathology in AD mouse models. However, small-animal PET imaging is limited by coarse spatial resolution. We have installed a custom-fabricated PET insert into our small-animal MRI instrument and used PET/MRI hybrid imaging to define regions of amyloid vulnerability in 5xFAD mice. We compared fluorine-18 [<sup>18</sup>F]-Florbetapir uptake in the 5xFAD brain by d ...[more]