Ontology highlight
ABSTRACT:
SUBMITTER: Wang SS
PROVIDER: S-EPMC5094982 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Wang Sophie Sw SS Wuputra Kenly K Liu Chung-Jung CJ Lin Yin-Chu YC Chen Yi-Ting YT Chai Chee-Yin CY Lin Chen-Lung Steve CS Kuo Kung-Kai KK Tsai Ming-Ho MH Wang Shin-Wei SW Chen Ker-Kong KK Miyoshi Hiroyuki H Nakamura Yukio Y Saito Shigeo S Hanafusa Tadashi T Wu Deng-Chyang DC Lin Chang-Shen CS Yokoyama Kazunari K KK
Oncotarget 20160601 24
To study the mechanisms of gastric tumorigenesis, we have established CSN cell line from human normal gastric mucosa, and CS12, a tumorigenic and invasive gastric cancer cell line from CSN passages. Many stem cell markers were expressed in both CSN and CS12 cells, but LGR5 and NANOG were expressed only in CS12 cells. Increased expression of homeobox A13 (HoxA13) and its downstream cascades was significant for the tumorigenic activity of CS12 cells, and was associated with recruitment of E2F-1 to ...[more]