Ontology highlight
ABSTRACT:
SUBMITTER: Ding X
PROVIDER: S-EPMC5095294 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Nature communications 20161027
Mammalian target of rapamycin (mTOR), a regulator of growth in many tissues, mediates its activity through two multiprotein complexes, mTORC1 or mTORC2. The role of mTOR signalling in skin morphogenesis and epidermal development is unknown. Here we identify mTOR as an essential regulator in skin morphogenesis by epidermis-specific deletion of Mtor in mice (mTOR<sup>EKO</sup>). mTOR<sup>EKO</sup> mutants are viable, but die shortly after birth due to deficits primarily during the early epidermal ...[more]