Ontology highlight
ABSTRACT:
SUBMITTER: Li M
PROVIDER: S-EPMC6804816 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Li Man M Lazorchak Adam S AS Ouyang Xinxing X Zhang Huihui H Liu Hongzhi H Arojo Omotooke A OA Yan Lichong L Jin Jingsi J Han Yuheng Y Qu Guojun G Fu Yuhong Y Xu Xiaocao X Liu Xiaobo X Zhang Wenqian W Yang Zhengfeng Z Ruan Chuan C Wang Qijun Q Liu Dou D Huang Chuanxin C Lu Lu L Jiang Shibo S Li Fubin F Su Bing B
Cellular & molecular immunology 20190131 9
Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity, but the underlying molecular mechanisms remain incompletely understood. In this study, Sin1, a key component of mTOR complex 2 (mTORC2), specifically regulates B cell growth and metabolism. Genetic ablation of Sin1 in B cells reduces the cell size at either the transitional stage or upon antigen stimulation and severely impairs metabolism. Sin1 deficiency also severely impairs B-cell proliferation, antibody r ...[more]