Ontology highlight
ABSTRACT:
SUBMITTER: Bergenstal RM
PROVIDER: S-EPMC5096008 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Bergenstal R M RM Lunt H H Franek E E Travert F F Mou J J Qu Y Y Antalis C J CJ Hartman M L ML Rosilio M M Jacober S J SJ Bastyr E J EJ
Diabetes, obesity & metabolism 20160803 11
<h4>Aims</h4>To compare the efficacy and safety of basal insulin peglispro (BIL), which has a flat pharmacokinetic and pharmacodynamic profile and a long duration of action, with insulin glargine (GL) in patients with type 1 diabetes.<h4>Materials and methods</h4>In this phase III, 52-week, blinded study, we randomized 1114 adults with type 1 diabetes in a 3 : 2 distribution to receive either BIL (n = 664) or GL (n = 450) at bedtime, with preprandial insulin lispro, using intensive insulin manag ...[more]