Ontology highlight
ABSTRACT:
SUBMITTER: Harris C
PROVIDER: S-EPMC5567880 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Harris Cynthia C Forst Thomas T Heise Tim T Plum-Mörschel Leona L Watkins Elaine E Zhang Qianyi Q Fan Ludi L Garhyan Parag P Porksen Niels N
Diabetes technology & therapeutics 20170801 8
<h4>Background</h4>Basal insulin peglispro (BIL) has a peripheral-to-hepatic distribution of action that resembles endogenous insulin and a prolonged duration of action with a flat pharmacokinetic/pharmacodynamic profile at steady state, characteristics that tend to reduce hypoglycemia risk compared to insulin glargine (GL). The primary objective was to demonstrate that clinically significant hypoglycemia (blood glucose ≤54 mg/dL [3.0 mmol/L] or symptoms of severe hypoglycemia) occurred less fre ...[more]