Ontology highlight
ABSTRACT:
SUBMITTER: Thurston TL
PROVIDER: S-EPMC5097160 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Thurston Teresa L M TL Matthews Sophie A SA Jennings Elliott E Alix Eric E Shao Feng F Shenoy Avinash R AR Birrell Mark A MA Holden David W DW
Nature communications 20161103
Sensing bacterial products in the cytosol of mammalian cells by NOD-like receptors leads to the activation of caspase-1 inflammasomes, and the production of the pro-inflammatory cytokines interleukin (IL)-18 and IL-1β. In addition, mouse caspase-11 (represented in humans by its orthologs, caspase-4 and caspase-5) detects cytosolic bacterial LPS directly. Activation of caspase-1 and caspase-11 initiates pyroptotic host cell death that releases potentially harmful bacteria from the nutrient-rich h ...[more]