Ontology highlight
ABSTRACT:
SUBMITTER: Shatz W
PROVIDER: S-EPMC5098433 | biostudies-literature | 2016 Nov/Dec
REPOSITORIES: biostudies-literature
Shatz Whitney W Ng Domingos D Dutina George G Wong Athena W AW Dunshee Diana Ronai DR Sonoda Junichiro J Shen Amy A Scheer Justin M JM
mAbs 20161101 8
Bispecific antibodies have shown promise in the clinic as medicines with novel mechanisms of action. Lack of efficient production of bispecific IgGs, however, has limited their rapid advancement. Here, we describe a single-reactor process using mammalian cell co-culture production to efficiently produce a bispecific IgG with 4 distinct polypeptide chains without the need for parallel processing of each half-antibody or additional framework mutations. This method resembles a conventional process, ...[more]