Ontology highlight
ABSTRACT:
SUBMITTER: Cruz JW
PROVIDER: S-EPMC6700171 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Cruz Jonathan W JW Damko Ermelinda E Modi Bhavika B Tu Naxin N Meagher Karoline K Voronina Vera V Gartner Hans H Ehrlich George G Rafique Ashique A Babb Robert R Aneja Priya P Potocky Terra B TB D' Orvilliers Amanda A Coppi Alida A E Sook Yen SY Qiu Haibo H Williams Courtney M CM Bennett Brandy L BL Chen Gang G Macdonald Lynn L Olson William W Lin John C JC Stahl Neil N Murphy Andrew J AJ Kyratsous Christos A CA Prasad Brinda C BC
Scientific reports 20190819 1
Harnessing complement-mediated cytotoxicity by therapeutic antibodies has been limited because of dependency on size and density of antigen, structural constraints resulting from orientation of antibody binding, and blockade of complement activation by inhibitors expressed on target cells. We developed a modular bispecific antibody platform that directs the complement-initiating protein C1q to target cells, increases local complement deposition and induces cytotoxicity against target antigens wi ...[more]