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A Simple Primary Amine Catalyst for Enantioselective ?-Hydroxylations and ?-Fluorinations of Branched Aldehydes.
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ABSTRACT:
SUBMITTER: Witten MR
PROVIDER: S-EPMC5098907 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
A Simple Primary Amine Catalyst for Enantioselective α-Hydroxylations and α-Fluorinations of Branched Aldehydes.
Organic letters 20150508 11
A new primary amine catalyst for the asymmetric α-hydroxylation and α-fluorination of α-branched aldehydes is described. The products of the title transformations are generated in excellent yields with high enantioselectivities. Both processes can be performed within short reaction times and on gram scale. The similarity in results obtained in both reactions, combined with computational evidence, implies a common basis for stereoinduction and the possibility of a general catalytic mechanism for ...[more]