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An Efficient Passerini Tetrazole Reaction (PT-3CR).

ABSTRACT: A sonication accelerated, catalyst free, simple, high yielding and efficient method for the Passerini-type three component reaction (PT-3CR) has been developed. It comprises reaction of an aldehyde/ketone, a isocyanide and a TMS-azide in methanol:water (1:1) as the solvent system. Use of sonication not only accelerated the rate of the reaction but also provided up to quantitative yields. This reaction is applicable to a broad scope of aldehyde/ketone and isocyanides.

SUBMITTER: Chandgude AL

PROVIDER: S-EPMC5102161 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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An Efficient Passerini Tetrazole Reaction (PT-3CR).

Chandgude Ajay L AL Dömling Alexander A

Green chemistry : an international journal and green chemistry resource : GC 20160519 13

A sonication accelerated, catalyst free, simple, high yielding and efficient method for the Passerini-type three component reaction (PT-3CR) has been developed. It comprises reaction of an aldehyde/ketone, a isocyanide and a TMS-azide in methanol:water (1:1) as the solvent system. Use of sonication not only accelerated the rate of the reaction but also provided up to quantitative yields. This reaction is applicable to a broad scope of aldehyde/ketone and isocyanides. ...[more]

PMID: 27840590

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