Ontology highlight
ABSTRACT:
SUBMITTER: Fraser LD
PROVIDER: S-EPMC5102633 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
European journal of immunology 20150624 8
The principles of allelic exclusion state that each B cell expresses a single light and heavy chain pair. Here, we show that B cells with both kappa and lambda light chains (Igκ and Igλ) are enriched in some patients with the systemic autoimmune disease systemic lupus erythematosus (SLE), but not in the systemic autoimmune disease control granulomatosis with polyangiitis. Detection of dual Igκ and Igλ expression by flow cytometry could not be abolished by acid washing or by DNAse treatment to re ...[more]