Ontology highlight
ABSTRACT:
SUBMITTER: Xu S
PROVIDER: S-EPMC7214812 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Frontiers in immunology 20200505
Systemic lupus erythematosus (SLE) is characterized by the overproduction of high-affinity autoreactive antibodies. Here, we show that more than 65.8% of 222 recombinant antibodies derived from 8 SLE patients can be secreted as heavy chain-only antibodies (HCAbs) when expressed in HEK-293T cells. The secretion of HCAbs follows the conventional endoplasmic reticulum-Golgi apparatus pathway, despite triggering a weaker unfolded protein response (UPR). Many of the purified SLE HCAbs remain autoreac ...[more]