Ontology highlight
ABSTRACT:
SUBMITTER: Widner FJ
PROVIDER: S-EPMC5103170 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20160629 37
B12 is unique among the vitamins as it is biosynthesized only by certain prokaryotes. The complexity of its synthesis relates to its distinctive cobalt corrin structure, which is essential for B12 biochemistry and renders coenzyme B12 (AdoCbl) so intriguingly suitable for enzymatic radical reactions. However, why is cobalt so fit for its role in B12 -dependent enzymes? To address this question, we considered the substitution of cobalt in AdoCbl with rhodium to generate the rhodium analogue 5'-de ...[more]