Ontology highlight
ABSTRACT:
SUBMITTER: Bayer-Santos E
PROVIDER: S-EPMC5104694 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Bayer-Santos Ethel E Durkin Charlotte H CH Rigano Luciano A LA Kupz Andreas A Alix Eric E Cerny Ondrej O Jennings Elliott E Liu Mei M Ryan Aindrias S AS Lapaque Nicolas N Kaufmann Stefan H E SHE Holden David W DW
Cell host & microbe 20161101 5
The SPI-2 type III secretion system (T3SS) of intracellular Salmonella enterica translocates effector proteins into mammalian cells. Infection of antigen-presenting cells results in SPI-2 T3SS-dependent ubiquitination and reduction of surface-localized mature MHC class II (mMHCII). We identify the effector SteD as required and sufficient for this process. In Mel Juso cells, SteD localized to the Golgi network and vesicles containing the E3 ubiquitin ligase MARCH8 and mMHCII. SteD caused MARCH8-d ...[more]