Ontology highlight
ABSTRACT:
SUBMITTER: Davis RA
PROVIDER: S-EPMC5111556 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Organic & biomolecular chemistry 20160901 37
Solid-phase peptide synthesis, head-to-tail cyclization, and subsequent radiolabeling provided a reproducible, simple, rapid synthetic method to generate the cyclic peptide radiotracer cRGDyK([<sup>18</sup>F]FBA). Herein is reported the first on-resin cyclization and <sup>18</sup>F-radiolabeling of a cyclic peptide (cRGDyK) in an overall peptide synthesis yield of 88% (cRGDyK(NH<sub>2</sub>)) and subsequent radiolabeling yield of 14 ± 2% (decay corrected, n = 4). This approach is generally appli ...[more]