Unmasking the U2AF homology motif family: a bona fide protein-protein interaction motif in disguise.
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ABSTRACT:
SUBMITTER: Loerch S
PROVIDER: S-EPMC5113200 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Unmasking the U2AF homology motif family: a bona fide protein-protein interaction motif in disguise.
Loerch Sarah S Kielkopf Clara L CL
RNA (New York, N.Y.) 20161201 12
U2AF homology motifs (UHM) that recognize U2AF ligand motifs (ULM) are an emerging family of protein-protein interaction modules. UHM-ULM interactions recur in pre-mRNA splicing factors including U2AF1 and SF3b1, which are frequently mutated in myelodysplastic syndromes. The core topology of the UHM resembles an RNA recognition motif and is often mistakenly classified within this large family. Here, we unmask the charade and review recent discoveries of UHM-ULM modules for protein-protein intera ...[more]
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