Ontology highlight
ABSTRACT:
SUBMITTER: Hefendehl JK
PROVIDER: S-EPMC5114608 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Nature communications 20161111
Amyloid-β (Aβ) plaques, a hallmark of Alzheimer's disease (AD), are surrounded by regions of neuronal and glial hyperactivity. We use in vivo two-photon and wide-field imaging of the glutamate sensor iGluSnFR to determine whether pathological changes in glutamate dynamics in the immediate vicinity of Aβ deposits in APPPS1 transgenic mice could alter neuronal activity in this microenvironment. In regions close to Aβ plaques chronic states of high spontaneous glutamate fluctuations are observed an ...[more]