Ontology highlight
ABSTRACT:
SUBMITTER: Dang J
PROVIDER: S-EPMC5116380 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Dang Jason J Tiwari Shashi Kant SK Lichinchi Gianluigi G Qin Yue Y Patil Veena S VS Eroshkin Alexey M AM Rana Tariq M TM
Cell stem cell 20160506 2
Emerging evidence from the current outbreak of Zika virus (ZIKV) indicates a strong causal link between Zika and microcephaly. To investigate how ZIKV infection leads to microcephaly, we used human embryonic stem cell-derived cerebral organoids to recapitulate early stage, first trimester fetal brain development. Here we show that a prototype strain of ZIKV, MR766, efficiently infects organoids and causes a decrease in overall organoid size that correlates with the kinetics of viral copy number. ...[more]