Ontology highlight
ABSTRACT:
SUBMITTER: Zhou T
PROVIDER: S-EPMC5553280 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Zhou Ting T Tan Lei L Cederquist Gustav Y GY Fan Yujie Y Hartley Brigham J BJ Mukherjee Suranjit S Tomishima Mark M Brennand Kristen J KJ Zhang Qisheng Q Schwartz Robert E RE Evans Todd T Studer Lorenz L Chen Shuibing S
Cell stem cell 20170720 2
Zika virus (ZIKV) infects fetal and adult human brain and is associated with serious neurological complications. To date, no therapeutic treatment is available to treat ZIKV-infected patients. We performed a high-content chemical screen using human pluripotent stem cell-derived cortical neural progenitor cells (hNPCs) and found that hippeastrine hydrobromide (HH) and amodiaquine dihydrochloride dihydrate (AQ) can inhibit ZIKV infection in hNPCs. Further validation showed that HH also rescues ZIK ...[more]