Ontology highlight
ABSTRACT:
SUBMITTER: Jin Z
PROVIDER: S-EPMC5117142 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Jin Zhigang Z Schwend Tyler T Fu Jia J Bao Zehua Z Liang Jing J Zhao Huimin H Mei Wenyan W Yang Jing J
Development (Cambridge, England) 20160915 21
Hedgehog (Hh) signaling is fundamentally important for development and adult tissue homeostasis. It is well established that in vertebrates Sufu directly binds and inhibits Gli proteins, the downstream mediators of Hh signaling. However, it is unclear how the inhibitory function of Sufu towards Gli is regulated. Here we report that the Rusc family of proteins, the biological functions of which are poorly understood, form a heterotrimeric complex with Sufu and Gli. Upon Hh signaling, Rusc is disp ...[more]