The 2016 John J. Abel Award Lecture: Targeting the Mechanical Microenvironment in Cancer.
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SUBMITTER: Majeski HE
PROVIDER: S-EPMC5118638 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
The 2016 John J. Abel Award Lecture: Targeting the Mechanical Microenvironment in Cancer.
Majeski Hannah E HE Yang Jing J
Molecular pharmacology 20161014 6
Past decades of cancer research have mainly focused on the role of various extracellular and intracellular biochemical signals on cancer progression and metastasis. Recent studies suggest an important role of mechanical forces in regulating cellular behaviors. This review first provides an overview of the mechanobiology research field. Then we specially focus on mechanotransduction pathways in cancer progression and describe in detail the key signaling components of such mechanotransduction path ...[more]
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