Ontology highlight
ABSTRACT:
SUBMITTER: Deming Y
PROVIDER: S-EPMC5118651 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Deming Yuetiva Y Xia Jian J Cai Yefei Y Lord Jenny J Holmans Peter P Bertelsen Sarah S Holtzman David D Morris John C JC Bales Kelly K Pickering Eve H EH Kauwe John J Goate Alison A Cruchaga Carlos C
Neurobiology of aging 20150925
Genome-wide association studies have associated clusterin (CLU) variants with Alzheimer's disease (AD). However, the role of CLU on AD pathogenesis is not totally understood. We used cerebrospinal fluid (CSF) and plasma CLU levels as endophenotypes for genetic studies to understand the role of CLU in AD. CSF, but not plasma, CLU levels were significantly associated with AD status and CSF tau/amyloid-beta ratio, and highly correlated with CSF apolipoprotein E (APOE) levels. Several loci showed al ...[more]