Ontology highlight
ABSTRACT:
SUBMITTER: Thomas JJ
PROVIDER: S-EPMC5125238 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Thomas Jane J JJ Abed Mona M Heuberger Julian J Novak Rostislav R Zohar Yaniv Y Beltran Lopez Angela P AP Trausch-Azar Julie S JS Ilagan Ma Xenia G MXG Benhamou David D Dittmar Gunnar G Kopan Raphael R Birchmeier Walter W Schwartz Alan L AL Orian Amir A
Cell reports 20160901 12
Ubiquitylation regulates signaling pathways critical for cancer development and, in many cases, targets proteins for degradation. Here, we report that ubiquitylation by RNF4 stabilizes otherwise short-lived oncogenic transcription factors, including β-catenin, Myc, c-Jun, and the Notch intracellular-domain (N-ICD) protein. RNF4 enhances the transcriptional activity of these factors, as well as Wnt- and Notch-dependent gene expression. While RNF4 is a SUMO-targeted ubiquitin ligase, protein stabi ...[more]