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Residential proximity to major roadways, fine particulate matter, and adiposity: The framingham heart study.

ABSTRACT: OBJECTIVE:Higher traffic-related air pollution has been associated with higher body mass index (BMI) among children. However, few studies have assessed the associations among adults. METHODS:Participants (N?=?2,372) from the Framingham Offspring and Third Generation cohorts who underwent multidetector-computed tomography scans (2002-2005) were included. Residential-based proximity to the nearest major roadway and 1-year average levels of fine particulate matter (PM2.5 ) air pollution were estimated. BMI was measured at Offspring examination 7 (1998-2001) and Third Generation examination 1 (2002-2005); subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) were measured using multidetector-computed tomography. Linear regression models were used for continuous BMI, SAT, and VAT and logistic models for the binary indicator of obesity (BMI ?30 kg/m2 ), adjusting for demographic variables, individual- and area-level measures of socioeconomic position, and clinical and lifestyle factors. RESULTS:Participants who lived 60 m from a major roadway had 0.37 kg/m2 higher BMI (95% CI: 0.10 to 0.65 kg/m2 ), 78.4 cm3 higher SAT (95% CI: 4.5 to 152.3 cm3 ), and 41.8 cm3 higher VAT (95% CI: -4.7 to 88.2 cm3 ) than those who lived 440 m away. CONCLUSIONS:Living closer to a major roadway was associated with higher overall and abdominal adiposity.

SUBMITTER: Li W

PROVIDER: S-EPMC5125859 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Residential proximity to major roadways, fine particulate matter, and adiposity: The framingham heart study.

Li Wenyuan W Dorans Kirsten S KS Wilker Elissa H EH Rice Mary B MB Schwartz Joel J Coull Brent A BA Koutrakis Petros P Gold Diane R DR Fox Caroline S CS Mittleman Murray A MA

Obesity (Silver Spring, Md.) 20161102 12

<h4>Objective</h4>Higher traffic-related air pollution has been associated with higher body mass index (BMI) among children. However, few studies have assessed the associations among adults.<h4>Methods</h4>Participants (N = 2,372) from the Framingham Offspring and Third Generation cohorts who underwent multidetector-computed tomography scans (2002-2005) were included. Residential-based proximity to the nearest major roadway and 1-year average levels of fine particulate matter (PM<sub>2.5</sub> ) ...[more]

PMID: 27804220

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Project description:Background and purposeThe evidence supporting the deleterious cardiovascular health effects of living near a major roadway is growing, although this association is not universal. In primary analyses, we hypothesized that residential proximity to a major roadway would be associated with incident ischemic stroke and that cardiovascular risk factors would modify that association.MethodsNOMAS (The Northern Manhattan Study) is an ongoing, population-based cohort study designed to measure cardiovascular risk factors, stroke incidence, and other outcomes in a multiethnic urban population. Recruitment occurred from 1993 to 2001 and participants are followed-up annually by telephone. Residential addresses at baseline were geocoded and Euclidean distance to nearest major roadway was estimated and categorized as in prior studies. We used Cox proportional hazard models to calculate hazard ratios and 95% confidence intervals for the association of this distance to incidence of stroke and other outcomes, adjusting for sociodemographic and cardiovascular risk factors, year at baseline, and neighborhood socioeconomic status. We assessed whether these associations varied by age, sex, smoking status, diabetes mellitus, and hypertension.ResultsDuring a median follow-up period of 15 years (n=3287), 11% of participants were diagnosed with ischemic stroke. Participants living <100 m from a roadway had a 42% (95% confidence interval, 1.01-2.02) higher rate of ischemic stroke versus those living >400 m away. This association was more pronounced among noncurrent smokers (hazard ratio, 1.54; 95% confidence interval, 1.05-2.26) and not evident among smokers (hazard ratio, 0.69; 95% confidence interval, 0.23-2.06). There was no clear pattern of association between proximity to major roadways and other cardiovascular events including myocardial infarction, all-cause death, or vascular death.ConclusionsIn this urban multiethnic cohort, we found evidence supporting that within-city variation in residential proximity to major roadway is associated with higher risk of ischemic stroke. An individual's smoking history modified this association, with the association remaining only among participants not currently smokers.

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Residential proximity to major roadways, fine particulate matter, and adiposity: The framingham heart study.

Publications

Residential proximity to major roadways, fine particulate matter, and adiposity: The framingham heart study.

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