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Residential proximity to major roadways and traffic in relation to outcomes of in vitro fertilization.

ABSTRACT: BACKGROUND:Emerging data from animal and human studies suggest that traffic-related air pollution adversely affects early pregnancy outcomes; however evidence is limited. OBJECTIVE:We examined whether residential proximity to major roadways and traffic, as proxies for traffic-related air pollution, are associated with in vitro fertilization (IVF) outcomes. METHODS:This analysis included 423 women enrolled in the Environment and Reproductive Health (EARTH) Study, a prospective cohort study, who underwent 726 IVF cycles (2004-2017). Using geocoded residential addresses collected at study entry, we calculated the distance to nearest major roadway and the traffic density within a 100?m radius. IVF outcomes were abstracted from electronic medical records. We used multivariable generalized linear mixed models to evaluate the associations between residential proximity to major roadways and traffic density and IVF outcomes adjusting for maternal age, body mass index, race, education level, smoking status, and census tract median income. RESULTS:Closer residential proximity to major roadways was statistically significantly associated with lower probability of implantation and live birth following IVF. The adjusted percentage of IVF cycles resulting in live birth for women living ?400?m from a major roadway was 46% (95% CI 36, 56%) compared to 33% (95% CI 26, 40%) for women living <50?m (p-for-comparison, 0.04). Of the intermediate outcomes, there were suggestive associations between living closer to major roadways and slightly higher estradiol trigger concentrations (p-trend?=?0.16) and lower endometrial thickness (p-trend?=?0.06). Near-residence traffic density was not associated with outcomes of IVF. CONCLUSION:Closer residential proximity to major roadways was related to reduced likelihood of live birth following IVF.

SUBMITTER: Gaskins AJ

PROVIDER: S-EPMC5970056 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Residential proximity to major roadways and traffic in relation to outcomes of in vitro fertilization.

Gaskins Audrey J AJ Hart Jaime E JE Mínguez-Alarcón Lidia L Chavarro Jorge E JE Laden Francine F Coull Brent A BA Ford Jennifer B JB Souter Irene I Hauser Russ R

Environment international 20180330

<h4>Background</h4>Emerging data from animal and human studies suggest that traffic-related air pollution adversely affects early pregnancy outcomes; however evidence is limited.<h4>Objective</h4>We examined whether residential proximity to major roadways and traffic, as proxies for traffic-related air pollution, are associated with in vitro fertilization (IVF) outcomes.<h4>Methods</h4>This analysis included 423 women enrolled in the Environment and Reproductive Health (EARTH) Study, a prospecti ...[more]

PMID: 29605676

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Project description:Background and purposeThe evidence supporting the deleterious cardiovascular health effects of living near a major roadway is growing, although this association is not universal. In primary analyses, we hypothesized that residential proximity to a major roadway would be associated with incident ischemic stroke and that cardiovascular risk factors would modify that association.MethodsNOMAS (The Northern Manhattan Study) is an ongoing, population-based cohort study designed to measure cardiovascular risk factors, stroke incidence, and other outcomes in a multiethnic urban population. Recruitment occurred from 1993 to 2001 and participants are followed-up annually by telephone. Residential addresses at baseline were geocoded and Euclidean distance to nearest major roadway was estimated and categorized as in prior studies. We used Cox proportional hazard models to calculate hazard ratios and 95% confidence intervals for the association of this distance to incidence of stroke and other outcomes, adjusting for sociodemographic and cardiovascular risk factors, year at baseline, and neighborhood socioeconomic status. We assessed whether these associations varied by age, sex, smoking status, diabetes mellitus, and hypertension.ResultsDuring a median follow-up period of 15 years (n=3287), 11% of participants were diagnosed with ischemic stroke. Participants living <100 m from a roadway had a 42% (95% confidence interval, 1.01-2.02) higher rate of ischemic stroke versus those living >400 m away. This association was more pronounced among noncurrent smokers (hazard ratio, 1.54; 95% confidence interval, 1.05-2.26) and not evident among smokers (hazard ratio, 0.69; 95% confidence interval, 0.23-2.06). There was no clear pattern of association between proximity to major roadways and other cardiovascular events including myocardial infarction, all-cause death, or vascular death.ConclusionsIn this urban multiethnic cohort, we found evidence supporting that within-city variation in residential proximity to major roadway is associated with higher risk of ischemic stroke. An individual's smoking history modified this association, with the association remaining only among participants not currently smokers.

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Residential proximity to major roadways and traffic in relation to outcomes of in vitro fertilization.

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Residential proximity to major roadways and traffic in relation to outcomes of in vitro fertilization.

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