Ontology highlight
ABSTRACT:
SUBMITTER: Zheng X
PROVIDER: S-EPMC5127643 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Zheng Xu X Krakowiak Joanna J Patel Nikit N Beyzavi Ali A Ezike Jideofor J Khalil Ahmad S AS Pincus David D
eLife 20161110
Heat shock factor (Hsf1) regulates the expression of molecular chaperones to maintain protein homeostasis. Despite its central role in stress resistance, disease and aging, the mechanisms that control Hsf1 activity remain unresolved. Here we show that in budding yeast, Hsf1 basally associates with the chaperone Hsp70 and this association is transiently disrupted by heat shock, providing the first evidence that a chaperone repressor directly regulates Hsf1 activity. We develop and experimentally ...[more]