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TG02 inhibits proteasome inhibitor-induced HSF1 serine 326 phosphorylation and heat shock response in multiple myeloma.


ABSTRACT: Proteasome inhibition activates multiple kinases in myeloma cells resulting in the phosphorylation of p53, HSP27, c-JUN, and HSF1.TG02 inhibits proteasome inhibitor (PI)-induced HSF1 pS326, representing a novel mechanism for a TG02 and PI combination.

SUBMITTER: Shah SP 

PROVIDER: S-EPMC5728095 | biostudies-literature |

REPOSITORIES: biostudies-literature

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