Ontology highlight
ABSTRACT:
SUBMITTER: Liebelt F
PROVIDER: S-EPMC6316133 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Liebelt Frauke F Sebastian Rebecca M RM Moore Christopher L CL Mulder Monique P C MPC Ovaa Huib H Shoulders Matthew D MD Vertegaal Alfred C O ACO
Cell reports 20190101 1
The role of stress-induced increases in SUMO2/3 conjugation during the heat shock response (HSR) has remained enigmatic. We investigated SUMO signal transduction at the proteomic and functional level during the HSR in cells depleted of proteostasis network components via chronic heat shock factor 1 inhibition. In the recovery phase post heat shock, high SUMO2/3 conjugation was prolonged in cells lacking sufficient chaperones. Similar results were obtained upon inhibiting HSP90, indicating that i ...[more]