Ontology highlight
ABSTRACT:
SUBMITTER: Lopez CA
PROVIDER: S-EPMC5127919 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Lopez Christopher A CA Miller Brittany M BM Rivera-Chávez Fabian F Velazquez Eric M EM Byndloss Mariana X MX Chávez-Arroyo Alfredo A Lokken Kristen L KL Tsolis Renée M RM Winter Sebastian E SE Bäumler Andreas J AJ
Science (New York, N.Y.) 20160915 6305
Citrobacter rodentium uses a type III secretion system (T3SS) to induce colonic crypt hyperplasia in mice, thereby gaining an edge during its competition with the gut microbiota through an unknown mechanism. Here, we show that by triggering colonic crypt hyperplasia, the C. rodentium T3SS induced an excessive expansion of undifferentiated Ki67-positive epithelial cells, which increased oxygenation of the mucosal surface and drove an aerobic C. rodentium expansion in the colon. Treatment of mice ...[more]