Ontology highlight
ABSTRACT:
SUBMITTER: Alam R
PROVIDER: S-EPMC5129484 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20161013 46
The catalytic asymmetric allylboration of cyclic imines with γ,γ-disubstituted allylboronic acids provides products with adjacent stereocenters in high yield and stereoselectivity. Various electrophiles, including 3,4-dihydroisoquinolines and indoles, were prenylated in a fully stereodivergent fashion by switching the E/Z geometry of the allylboronate and/or the enantiomer of the BINOL catalyst. 3-Methylindole provided products with three adjacent stereocenters with high stereoselectivity in one ...[more]