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CryoEM Structure of mGlu2 - Gi Complex

ABSTRACT:

SUBMITTER: Georgios Skiniotis

PROVIDER: EMPIAR-10979 | biostudies-other |

REPOSITORIES: biostudies-other

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G-protein activation by a metabotropic glutamate receptor.

Seven Alpay B AB Barros-Álvarez Ximena X de Lapeyrière Marine M Papasergi-Scott Makaía M MM Robertson Michael J MJ Zhang Chensong C Nwokonko Robert M RM Gao Yang Y Meyerowitz Justin G JG Rocher Jean-Philippe JP Schelshorn Dominik D Kobilka Brian K BK Mathiesen Jesper M JM Skiniotis Georgios G

Nature 20210630 7867

Family C G-protein-coupled receptors (GPCRs) operate as obligate dimers with extracellular domains that recognize small ligands, leading to G-protein activation on the transmembrane (TM) domains of these receptors by an unknown mechanism<sup>1</sup>. Here we show structures of homodimers of the family C metabotropic glutamate receptor 2 (mGlu2) in distinct functional states and in complex with heterotrimeric G<sub>i</sub>. Upon activation of the extracellular domain, the two transmembrane domain ...[more]

PMID: 34194039

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| S-EPMC5129878 | biostudies-literature

CryoEM Structure of Full-Length mGlu2 in Inactive-State Bound to Antagonist LY341495