Ontology highlight
ABSTRACT:
SUBMITTER: Shu X
PROVIDER: S-EPMC5131569 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20161013 46
Cisplatin, one of the most widely used anticancer drugs, crosslinks DNA and ultimately induces cell death. However, the genomic pattern of cisplatin-DNA adducts has remained unknown owing to the lack of a reliable and sensitive genome-wide method. Herein we present "cisplatin-seq" to identify genome-wide cisplatin crosslinking sites at base resolution. Cisplatin-seq reveals that mitochondrial DNA is a preferred target of cisplatin. For nuclear genomes, cisplatin-DNA adducts are enriched within p ...[more]