Ontology highlight
ABSTRACT:
SUBMITTER: Kawoos U
PROVIDER: S-EPMC5132256 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Kawoos Usmah U Gu Ming M Lankasky Jason J McCarron Richard M RM Chavko Mikulas M
PloS one 20161201 12
Exposure to blast overpressure (BOP) activates a cascade of pathological processes including changes in intracranial pressure (ICP) and blood-brain barrier (BBB) permeability resulting in traumatic brain injury (TBI). In this study the effect of single and multiple exposures at two intensities of BOP on changes in ICP and BBB permeability in Sprague-Dawley rats was evaluated. Animals were exposed to a single or three repetitive (separated by 0.5 h) BOPs at 72 kPa or 110 kPa. ICP was monitored co ...[more]