Ontology highlight
ABSTRACT:
SUBMITTER: Cao X
PROVIDER: S-EPMC5137455 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Cao Xiaocong X Li Yajuan Y Jin Xiangyu X Li Yuelong Y Guo Feng F Jin Tengchuan T
Nucleic acids research 20161019 21
Zika virus has attracted increasing attention because of its potential for causing human neural disorders, including microcephaly in infants and Guillain-Barré syndrome. Its NS3 helicase domain plays critical roles in NTP-dependent RNA unwinding and translocation during viral replication. Our structural analysis revealed a pre-activation state of NS3 helicase in complex with GTPγS, in which the triphosphate adopts a compact conformation in the absence of any divalent metal ions. In contrast, in ...[more]