Ontology highlight
ABSTRACT:
SUBMITTER: Mundi PS
PROVIDER: S-EPMC5137819 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Mundi Prabhjot S PS Sachdev Jasgit J McCourt Carolyn C Kalinsky Kevin K
British journal of clinical pharmacology 20160627 4
The phosphatidylinositol-3 kinase (PI3K)-AKT pathway is one of the most commonly dysregulated pathways in all of cancer, with somatic mutations, copy number alterations, aberrant epigenetic regulation and increased expression in a number of cancers. The carefully maintained homeostatic balance of cell division and growth on one hand, and programmed cell death on the other, is universally disturbed in tumorigenesis, and downstream effectors of the PI3K-AKT pathway play an important role in this d ...[more]