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? Association Between Neuregulin-1 Gene Variant ??(rs2439272) and Schizophrenia and Its Negative ?Symptoms in an Iranian Population.

ABSTRACT: Objective: Although the etiology of schizophrenia is unknown, it has a significant genetic component. ?A number of studies have indicated that neuregulin-1 (NRG1) gene may play a role in the ?pathogenesis of schizophrenia. In this study, we examined whether the rs2439272 of NRG1 ?is associated with schizophrenia and its negative symptoms in an Iranian population.? Method: Rs2439272 was genotyped in 469 participants including 276 unrelated patients with schizophrenia and 193 healthy controls. The association of genetic risk with negative ?symptoms (by using panss) was examined in the total, male and female samples. COCAPHASE and ?CLUMP22 programs were used to compare the allele and genotype frequencies, and ?general linear regression was used to analyze the quantitative dependent variables by the ?selected variant.? Results: In this study, it was revealed that the G allele of rs2439272 might be an allele with the ?increased risk of developing schizophrenia, especially in the male participants. In addition, ?significant differences were found between the G allele and GG genotype frequencies, and negative symptoms in the total and male participants.? Conclusion: Our results supported the association between rs2439272 in NRG1 gene and risk of ?schizophrenia and its negative symptoms in an Iranian population. ?.

SUBMITTER: Yoosefee S

PROVIDER: S-EPMC5139949 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Publications

‎ Association Between Neuregulin-1 Gene Variant ‎‎(rs2439272) and Schizophrenia and Its Negative ‎Symptoms in an Iranian Population.

Yoosefee Sadegh S Shahsavand Ananloo Esmaeil E Joghataei Mohammad-Taghi MT Karimipour Morteza M Hadjighassem Mahmoudreza M Mohaghghegh Hoorie H Tehrani-Doost Mehdi M Rahimi Amir-Abbas AA Mostafavi Abdolmaleky Hamid H Hatami Maryam M

Iranian journal of psychiatry 20160701 3

<b>Objective:</b> Although the etiology of schizophrenia is unknown, it has a significant genetic component. ‎A number of studies have indicated that neuregulin-1 (NRG1) gene may play a role in the ‎pathogenesis of schizophrenia. In this study, we examined whether the rs2439272 of NRG1 ‎is associated with schizophrenia and its negative symptoms in an Iranian population.‎ <b>Method:</b> Rs2439272 was genotyped in 469 participants including 276 unrelated patients with schizophrenia and 193 healthy ...[more]

PMID: 27928246

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Project description:BackgroundTumor necrosis factor-alpha (TNF-α) is an important cytokine in acute inflammatory response to infective factors. Based on investigation in different populations, it is thought that this response increases in patients with endometriosis due to the presence of cytokines such as TNF-α. This study aimed to examine the association of four TNF-α polymorphisms, namely -238G/A, -308G/A, -857C/T and -863C/A, with susceptibility to endometriosis in an Iranian population.Materials and methodsWe recruited 150 women with endometriosis and 150 women without endometriosis in this case-control study and collected 4 ml of blood from all subjects. After DNA extraction, the polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).ResultsThe allele frequency of TNF-α -863C/A in the case and control groups showed a significant difference [odds ratios (OR)=0.64, 95% confidence interval (CI)=0.41-0.99, P=0.047] but the result is not significant when Adjusting for multiple testing (P=0.188). No significant difference in the allele frequencies of -238G/A (OR=1.07, 95% CI=0.51-2.25, P=0.862), -308G/A (OR=0.79, 95% CI=0.43-1.45, P=0.438) and -857C/T (OR=1.03, 95% CI=0.66- 1.61, P=0.887) was observed. We adjusted all four polymorphism genotypes by age and body mass index (BMI), however, no significant difference was detected. There was an association between the case and control and BMI when adjusting by age (OR=1.082, 95% CI=1.009-1.162, P=0.028).ConclusionFor the first time the association of the four polymorphisms in the promoter region of the TNF-α gene with endometriosis has been conducted in women of Iranian origin. The present research reveals the -863 A allele may play a role in incidence of endometriosis among Iranian women. Development of endometriosis among those people with -863 A allele seems low. According to the results, the current study indicates that there might be a correlation between BMI and progression of endometriosis.

Dataset Information

? Association Between Neuregulin-1 Gene Variant ??(rs2439272) and Schizophrenia and Its Negative ?Symptoms in an Iranian Population.

Publications

‎ Association Between Neuregulin-1 Gene Variant ‎‎(rs2439272) and Schizophrenia and Its Negative ‎Symptoms in an Iranian Population.

Similar Datasets

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