Birth weight and risk of ischemic heart disease: A Mendelian randomization study.
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ABSTRACT:
SUBMITTER: Au Yeung SL
PROVIDER: S-EPMC5141503 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Birth weight and risk of ischemic heart disease: A Mendelian randomization study.
Au Yeung Shiu Lun SL Lin Shi Lin SL Li Albert Martin AM Schooling C Mary CM
Scientific reports 20161207
Low birth weight is a risk factor for cardiovascular disease. However, the association could be confounded by many factors. We used Mendelian randomization to clarify the role of birth weight in ischemic heart disease (IHD) and lipids. We used all 7 single nucleotide polymorphisms (SNPs) independently contributing to birth weight at genome wide significance (p < 5 × 10<sup>-8</sup>) in separate sample instrumental variable analysis to estimate the effect of birth weight on IHD using the CARDIoGR ...[more]
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